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Best hotels in Southeast Missouri

Hampton Inn Farmington image

Hampton Inn Farmington

Hotel
Hotel
8.3
Very Good
850 Valley Creek Dr, MO, 63640, United States Of America
Comfort Inn Festus - St Louis South image

Comfort Inn Festus - St Louis South

Hotel
Hotel
7.1
Good
1303 Veterans Blvd, MO, 63028, United States Of America
Comfort Suites Jackson-Cape Girardeau image

Comfort Suites Jackson-Cape Girardeau

Hotel
Hotel
7.3
Good
2904 Old Orchard Rd, MO, 63755, United States Of America
Quality Inn Charleston - Sikeston image

Quality Inn Charleston - Sikeston

Hotel
Hotel
6.2
Fair
102 Drake St, I-57 Exit 10, MO, 63834, United States Of America
Super 8 by Wyndham Charleston/Sikeston East MO image

Super 8 by Wyndham Charleston/Sikeston East MO

Motel
Motel
4.9
Fair
310 S Story St, MO, 63834, United States Of America
Quality Inn Hayti North image

Quality Inn Hayti North

Hotel
Hotel
5.5
Fair
1500 Highway 84, MO, 63851, United States Of America
Comfort Inn Poplar Bluff North image

Comfort Inn Poplar Bluff North

Hotel
Hotel
7.1
Good
2582 N Westwood Blvd, MO, 63901, United States Of America
Comfort Inn & Suites Sikeston I-55 image

Comfort Inn & Suites Sikeston I-55

Hotel
Hotel
8.4
Very Good
109 Matthews Ln, MO, 63801, United States Of America
Candlewood Suites Cape Girardeau, an IHG Hotel image

Candlewood Suites Cape Girardeau, an IHG Hotel

Hotel
Hotel
8
Very Good
485 S Mount Auburn Rd, MO, 65703, United States Of America
Days Inn by Wyndham Perryville image

Days Inn by Wyndham Perryville

Hotel
Hotel
6.1
Fair
1500 Liberty Street, MO, 63775, United States Of America
Super 8 by Wyndham Potosi image

Super 8 by Wyndham Potosi

Motel
Motel
7
Good
820 E High St, MO, 63664, United States Of America
Super 8 by Wyndham Farmington image

Super 8 by Wyndham Farmington

Motel
Motel
7.5
Good
930 Valley Creek Dr, MO, 63640, United States Of America
Baymont Inn and Suites by Wyndham Farmington, MO image

Baymont Inn and Suites by Wyndham Farmington, MO

Hotel
Hotel
7.6
Good
1625 W Columbia St, MO, 63640, United States Of America
Super 8 by Wyndham Pevely image

Super 8 by Wyndham Pevely

Motel
Motel
5.1
Fair
1711 Highway Z, MO, 63070, United States Of America
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS, an IHG Hotel image

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS, an IHG Hotel

Hotel
Hotel
9
Very Good
1802 Gamel Cemetery Road, MO, 63028, United States Of America
Quality Inn image

Quality Inn

Hotel
Hotel
6.7
Fair
2011 North Kingshighway, MO, 63701, United States Of America
Holiday Inn Poplar Bluff, an IHG Hotel image

Holiday Inn Poplar Bluff, an IHG Hotel

Hotel
Hotel
8.3
Very Good
2781 N Westwood Blvd, MO, 63901, United States Of America
Hampton Inn Poplar Bluff image

Hampton Inn Poplar Bluff

Hotel
Hotel
8.8
Very Good
2420 Crestwood Dr, MO, 63901, United States Of America
Super 8 by Wyndham Poplar Bluff Missouri image

Super 8 by Wyndham Poplar Bluff Missouri

Motel
Motel
5.5
Fair
2831 N Westwood Blvd, MO, 63901, United States Of America
Super 8 by Wyndham Sikeston/Miner Area image

Super 8 by Wyndham Sikeston/Miner Area

Hotel
Hotel
6.6
Fair
2609 E Malone Ave, MO, 63801, United States Of America
Holiday Inn Club Vacations Timber Creek Resort at De Soto, an IHG Hotel image

Holiday Inn Club Vacations Timber Creek Resort at De Soto, an IHG Hotel

Aparthotel
Aparthotel
9.2
Outstanding
4800 U.S. Highway 67, MO, 63020, United States Of America
Best Western Plus Sikeston image

Best Western Plus Sikeston

Hotel
Hotel
7.6
Good
120 S Interstate Drive, MO, 63801, United States Of America
Hampton Inn Cape Girardeau I 55 East image

Hampton Inn Cape Girardeau I 55 East

Hotel
Hotel
9.3
Outstanding
207 S Mt Auburn Rd, MO, 63703, United States Of America
Super 8 by Wyndham Perryville image

Super 8 by Wyndham Perryville

Motel
Motel
7.9
Good
1119 Vincent Dr, MO, 63775, United States Of America
Super 8 by Wyndham Kennett image

Super 8 by Wyndham Kennett

Motel
Motel
5.8
Fair
1808 1st St, MO, 63857, United States Of America
12

Brief description of Southeast Missouri

Discover the charm of Southeast Missouri, where rolling hills meet scenic rivers for the perfect getaway! Enjoy the warm hospitality as you explore local attractions and vibrant culture while staying in cozy hotels at fantastic prices.

What makes Southeast Missouri so popular

Southeast Missouri is known for its stunning natural landscapes, outdoor recreation, and rich cultural heritage including arts, history, and traditional Southern cuisine.

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